The NHS have greenlighted the use of a triple strength Wegovy jab, but it isn't without controversy.
Two trials compared the 2.4mg dose of the drug semaglutide, currently available under the brand name Wegovy, with a higher dose of 7.2mg and found that the higher dose helped some patients lose a quarter of their body weight.
The 7.2mg dose led to an average weight loss of nearly 19 percent, compared to the 16 percent weight loss seen with the 2.4mg Wegovy dose. But critics are sceptical, with many saying it's a step "too far".
However, for some desperate slimmers, they feel like its the only option left.
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Louise Temlett has been losing weight for 12 months on the jabs, but noticed she was started plateauing after swapping from Moujaro to Wegovy. She says she hasn't seen any results for the past few months while on Wegovy, despite still paying £99 a month.
The 42-year-old said she feels strongly about the UK making the triple dose readily available and said it's "about time". Originally taking Mounjaro, Louise, a Brazillian Ju Jitsu trainer and podcast host was left frustrated with the price hike from £99 a month to £329 a month.
"There was no way I could continue, so I had to switch to Wegovy for £99 a month, but it felt unfair they were putting the prices up and I didnt have the funds to progress with Mounjaro," she told the Mirror.
The mum-of-two weighed just over 15st 7lbs before she started taking the medication, and struggled to stop eating when she was full. "I was brought up in the 80s and 90s and my parents were quite Victorian, so anything on my plate I had to eat. During my weight loss, I had to unpick this mindset about leaving food on my plate and now I don't feel guilt for leaving food, I am no longer over-eating and the biggest shift for me is not now needing to snack."
"I was training Ju Jitsu and taking the medication and lost five stone. The first stone was purely looking after myslf and sleep and nutrition, and have now lost 20 kilos (3.1st) in last 12 months, but I am convinced it would have been more if I stayed on Mounjaro.
"When my clinicians noticed the Wegovy wasn't having the same effect when swapping, I was asked to get my bloods checked and they were fine, it was just the swap to Wegovy and the different dose. It's not a a surprise it wasn't working, it just isn't as effective as Mounjaro.
"I just want to be fitter and more active in my later years for my kids, fighting women who are younger than me and being able to do more of what I want to do now in my 50s, 60s, and 70s. Longevity is about strength and wellbeing and the less weight I am holding now means more years to live for my children."
Lousie explained how she was taking 12.5mg of Mounjaro, but had to jump down to 2.4mg of Wegovy to keep the costs low. "Everyone is stalling on Wegovy with 0 success, so I think it's a good idea it's coming up to the levels of what Mounjaro does."
With the new triple dose, the trial concluded the dose was generally safe. Side effects like nausea and diarrhoea and some sensory symptoms like tingling were recorded. However there was no increase in "serious adverse events" at the higher dose.
Dr Simon Cork, Senior Lecturer in Physiology at Anglia Ruskin University, said: "This suggests that patients with higher body mass, who would benefit most from more substantial weight loss, may benefit more from high dose semaglutide than that which is currently available.
"It is noteworthy, but not surprising that more patients on the higher dose experienced side effects such as nausea and vomiting compared to the lower dose." Serious but less common side-effects of semaglutide include acute gallstone disease, pancreatitis and serious allergic reactions. Researchers were trying to find out whether these were more likely at the increased dosage.
Most side effects observed in trials were manageable, resolved over time and did not lead to participants dropping out. No increase in serious adverse events or severe hypoglycaemia - abnormally low blood sugar levels - was observed with the higher dose.
While the new Wegovy dose has been green lighted by the NHS, critics say it's "going too far" with these drugs. But Louise disagrees. "I dont think it's going too far. It's only going as far as the highest dose of Mounjaro. It's still a legitimate dose and yes you might need to inject from three different needles but that's more of a supplier issue.
"By having these drugs, it doesn't just magically change everything, you still have to change your lifestyle habits too," and said. "When people have opinions without experience of these drugs, there's lots of misinterpretation, but until you suffer from obesity and see what different it makes that's when you can have an opinion."
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