Weight-loss drugs can cut heart patients' risk of early death
31 Aug 2025

A recent study has found that weight loss drugs can significantly reduce the risk of hospitalization or early death in heart patients, with semaglutide reducing the risk by 42% and tirzepatide by 58%.

The research, presented at the world's largest heart conference in Madrid, focused on a class of drugs called GLP-1 agonists.

These medications mimic the glucagon-like peptide (GLP) 1 hormone to induce a feeling of fullness and were initially developed for diabetes treatment.

Study based on real-world data
Research findings

The study, conducted by US researchers from Mass General Brigham, looked at real-world data from over 90,000 obese heart failure patients with type 2 diabetes.

It found that those taking semaglutide were 42% less likely to be hospitalized or die early than a proxy for placebo.

Meanwhile, tirzepatide reduced the risk of hospitalization for heart failure or death from any cause by an impressive 58%.

GLP-1 targeting medications could be much-needed treatment option
Potential impact

The study's author, Dr. Nils Kruger of Brigham and Women's Hospital, said that the findings show GLP-1 targeting medications could be a much-needed treatment option for heart failure patients.

He added that while semaglutide and tirzepatide are already known for their weight loss and blood sugar control effects, they might also provide substantial benefits to those with obesity and type 2 diabetes by reducing adverse heart failure outcomes.

More evidence needed before recommending to heart patients
Expert opinions

Dr. Carlos Aguiar, Vice-President of the European Society of Cardiology, welcomed the study's findings but stressed that more evidence is needed before weight loss drugs can be recommended to heart patients specifically to reduce their risk of adverse health outcomes.

Dr. Sonya Babu-Narayan, Clinical Director at the British Heart Foundation, also emphasized ensuring eligible heart failure patients are considered for these therapies along with other evidence-based heart failure medicines.